Journal: The Cochrane Database of Systematic Reviews

Article Title: Combination formoterol and budesonide as maintenance and reliever therapy versus current best practice (including inhaled steroid maintenance), for chronic asthma in adults and children

doi: 10.1002/14651858.CD007313.pub3

Figure Lengend Snippet: DE‐SOLO

Article Snippet: This was done consecutively from a centre specific randomisation listing, previously designed by AstraZeneca biometrical Unit All patients were rigorously assigned in a sequential manner, and always having previously checked that they met eligibility criteria." (Information provided by sponsors) Blinding (performance bias and detection bias) All outcomes High risk Open‐study design Incomplete outcome data (attrition bias) All outcomes High risk 58/328 (18%) on SiT did not complete the study, compared to 37/326 (11%) on conventional best practice Selective reporting (reporting bias) Low risk Data have been obtained for all primary outcome measures Open in a separate window SPAIN .

Techniques: Comparison, Control, Sequencing, Selection, Generated

Journal: The Cochrane Database of Systematic Reviews

Article Title: Combination formoterol and budesonide as maintenance and reliever therapy versus current best practice (including inhaled steroid maintenance), for chronic asthma in adults and children

doi: 10.1002/14651858.CD007313.pub3

Figure Lengend Snippet: MONO

Article Snippet: This was done consecutively from a centre specific randomisation listing, previously designed by AstraZeneca biometrical Unit All patients were rigorously assigned in a sequential manner, and always having previously checked that they met eligibility criteria." (Information provided by sponsors) Blinding (performance bias and detection bias) All outcomes High risk Open‐study design Incomplete outcome data (attrition bias) All outcomes High risk 58/328 (18%) on SiT did not complete the study, compared to 37/326 (11%) on conventional best practice Selective reporting (reporting bias) Low risk Data have been obtained for all primary outcome measures Open in a separate window SPAIN .

Techniques: Medications, Control, Sequencing, Selection, Generated

Journal: The Cochrane Database of Systematic Reviews

Article Title: Combination formoterol and budesonide as maintenance and reliever therapy versus current best practice (including inhaled steroid maintenance), for chronic asthma in adults and children

doi: 10.1002/14651858.CD007313.pub3

Figure Lengend Snippet: PASSION

Article Snippet: This was done consecutively from a centre specific randomisation listing, previously designed by AstraZeneca biometrical Unit All patients were rigorously assigned in a sequential manner, and always having previously checked that they met eligibility criteria." (Information provided by sponsors) Blinding (performance bias and detection bias) All outcomes High risk Open‐study design Incomplete outcome data (attrition bias) All outcomes High risk 58/328 (18%) on SiT did not complete the study, compared to 37/326 (11%) on conventional best practice Selective reporting (reporting bias) Low risk Data have been obtained for all primary outcome measures Open in a separate window SPAIN .

Techniques: Control, Comparison, Sequencing, Selection

Journal: The Cochrane Database of Systematic Reviews

Article Title: Combination formoterol and budesonide as maintenance and reliever therapy versus current best practice (including inhaled steroid maintenance), for chronic asthma in adults and children

doi: 10.1002/14651858.CD007313.pub3

Figure Lengend Snippet: SALTO

Article Snippet: This was done consecutively from a centre specific randomisation listing, previously designed by AstraZeneca biometrical Unit All patients were rigorously assigned in a sequential manner, and always having previously checked that they met eligibility criteria." (Information provided by sponsors) Blinding (performance bias and detection bias) All outcomes High risk Open‐study design Incomplete outcome data (attrition bias) All outcomes High risk 58/328 (18%) on SiT did not complete the study, compared to 37/326 (11%) on conventional best practice Selective reporting (reporting bias) Low risk Data have been obtained for all primary outcome measures Open in a separate window SPAIN .

Techniques: Control, Sequencing, Selection, Generated

Journal: The Cochrane Database of Systematic Reviews

Article Title: Combination formoterol and budesonide as maintenance and reliever therapy versus current best practice (including inhaled steroid maintenance), for chronic asthma in adults and children

doi: 10.1002/14651858.CD007313.pub3

Figure Lengend Snippet: SOLO

Article Snippet: This was done consecutively from a centre specific randomisation listing, previously designed by AstraZeneca biometrical Unit All patients were rigorously assigned in a sequential manner, and always having previously checked that they met eligibility criteria." (Information provided by sponsors) Blinding (performance bias and detection bias) All outcomes High risk Open‐study design Incomplete outcome data (attrition bias) All outcomes High risk 58/328 (18%) on SiT did not complete the study, compared to 37/326 (11%) on conventional best practice Selective reporting (reporting bias) Low risk Data have been obtained for all primary outcome measures Open in a separate window SPAIN .

Techniques: Biomarker Discovery, Medications, Sequencing, Selection, Generated

Journal: The Cochrane Database of Systematic Reviews

Article Title: Combination formoterol and budesonide as maintenance and reliever therapy versus current best practice (including inhaled steroid maintenance), for chronic asthma in adults and children

doi: 10.1002/14651858.CD007313.pub3

Figure Lengend Snippet: SPAIN

Article Snippet: This was done consecutively from a centre specific randomisation listing, previously designed by AstraZeneca biometrical Unit All patients were rigorously assigned in a sequential manner, and always having previously checked that they met eligibility criteria." (Information provided by sponsors) Blinding (performance bias and detection bias) All outcomes High risk Open‐study design Incomplete outcome data (attrition bias) All outcomes High risk 58/328 (18%) on SiT did not complete the study, compared to 37/326 (11%) on conventional best practice Selective reporting (reporting bias) Low risk Data have been obtained for all primary outcome measures Open in a separate window SPAIN .

Techniques: Control, Comparison, Sequencing, Selection

Journal: The Cochrane Database of Systematic Reviews

Article Title: Combination formoterol and budesonide as maintenance and reliever therapy versus current best practice (including inhaled steroid maintenance), for chronic asthma in adults and children

doi: 10.1002/14651858.CD007313.pub3

Figure Lengend Snippet: STYLE

Article Snippet: This was done consecutively from a centre specific randomisation listing, previously designed by AstraZeneca biometrical Unit All patients were rigorously assigned in a sequential manner, and always having previously checked that they met eligibility criteria." (Information provided by sponsors) Blinding (performance bias and detection bias) All outcomes High risk Open‐study design Incomplete outcome data (attrition bias) All outcomes High risk 58/328 (18%) on SiT did not complete the study, compared to 37/326 (11%) on conventional best practice Selective reporting (reporting bias) Low risk Data have been obtained for all primary outcome measures Open in a separate window SPAIN .

Techniques: Comparison, Biomarker Discovery, Control, Sequencing, Selection, Generated

Journal: The Cochrane Database of Systematic Reviews

Article Title: Combination formoterol and budesonide as maintenance and reliever therapy versus current best practice (including inhaled steroid maintenance), for chronic asthma in adults and children

doi: 10.1002/14651858.CD007313.pub3

Figure Lengend Snippet: SYMPHONIE

Article Snippet: This was done consecutively from a centre specific randomisation listing, previously designed by AstraZeneca biometrical Unit All patients were rigorously assigned in a sequential manner, and always having previously checked that they met eligibility criteria." (Information provided by sponsors) Blinding (performance bias and detection bias) All outcomes High risk Open‐study design Incomplete outcome data (attrition bias) All outcomes High risk 58/328 (18%) on SiT did not complete the study, compared to 37/326 (11%) on conventional best practice Selective reporting (reporting bias) Low risk Data have been obtained for all primary outcome measures Open in a separate window SPAIN .

Techniques: Control, Comparison, Sequencing, Selection, Generated

Journal: The Cochrane Database of Systematic Reviews

Article Title: Parenteral versus oral iron therapy for adults and children with chronic kidney disease

doi: 10.1002/14651858.CD007857.pub3

Figure Lengend Snippet:

Article Snippet: Random sequence generation (selection bias) , Low risk , Simple block randomisation from block randomisation lists generated with Graphpad Statmate.

Techniques: Sequencing, Selection, Generated, Introduce

Journal: The Cochrane Database of Systematic Reviews

Article Title: Parenteral versus oral iron therapy for adults and children with chronic kidney disease

doi: 10.1002/14651858.CD007857.pub3

Figure Lengend Snippet: Aggarwal 2003 CKD

Article Snippet: Random sequence generation (selection bias) , Low risk , Simple block randomisation from block randomisation lists generated with Graphpad Statmate.

Techniques: Direct Antiglobulin Test, Sequencing, Selection

Journal: The Cochrane Database of Systematic Reviews

Article Title: Parenteral versus oral iron therapy for adults and children with chronic kidney disease

doi: 10.1002/14651858.CD007857.pub3

Figure Lengend Snippet: Ahsan 1997 TX

Article Snippet: Random sequence generation (selection bias) , Low risk , Simple block randomisation from block randomisation lists generated with Graphpad Statmate.

Techniques: Sequencing, Selection

Journal: The Cochrane Database of Systematic Reviews

Article Title: Parenteral versus oral iron therapy for adults and children with chronic kidney disease

doi: 10.1002/14651858.CD007857.pub3

Figure Lengend Snippet: Broumand 1998 HD

Article Snippet: Random sequence generation (selection bias) , Low risk , Simple block randomisation from block randomisation lists generated with Graphpad Statmate.

Techniques: Infection, Sequencing, Selection

Journal: The Cochrane Database of Systematic Reviews

Article Title: Parenteral versus oral iron therapy for adults and children with chronic kidney disease

doi: 10.1002/14651858.CD007857.pub3

Figure Lengend Snippet: Erten 1998 HD

Article Snippet: Random sequence generation (selection bias) , Low risk , Simple block randomisation from block randomisation lists generated with Graphpad Statmate.

Techniques: Sequencing, Selection

Journal: The Cochrane Database of Systematic Reviews

Article Title: Parenteral versus oral iron therapy for adults and children with chronic kidney disease

doi: 10.1002/14651858.CD007857.pub3

Figure Lengend Snippet: Fishbane 1995 HD

Article Snippet: Random sequence generation (selection bias) , Low risk , Simple block randomisation from block randomisation lists generated with Graphpad Statmate.

Techniques: Sequencing, Selection

Journal: The Cochrane Database of Systematic Reviews

Article Title: Parenteral versus oral iron therapy for adults and children with chronic kidney disease

doi: 10.1002/14651858.CD007857.pub3

Figure Lengend Snippet: Fudin 1998 HD

Article Snippet: Random sequence generation (selection bias) , Low risk , Simple block randomisation from block randomisation lists generated with Graphpad Statmate.

Techniques: Sequencing, Selection, Generated

Journal: The Cochrane Database of Systematic Reviews

Article Title: Parenteral versus oral iron therapy for adults and children with chronic kidney disease

doi: 10.1002/14651858.CD007857.pub3

Figure Lengend Snippet: Hussain 1998 HD

Article Snippet: Random sequence generation (selection bias) , Low risk , Simple block randomisation from block randomisation lists generated with Graphpad Statmate.

Techniques: Sequencing, Selection

Journal: The Cochrane Database of Systematic Reviews

Article Title: Parenteral versus oral iron therapy for adults and children with chronic kidney disease

doi: 10.1002/14651858.CD007857.pub3

Figure Lengend Snippet: Kotaki 1997 HD

Article Snippet: Random sequence generation (selection bias) , Low risk , Simple block randomisation from block randomisation lists generated with Graphpad Statmate.

Techniques: Sequencing, Selection

Journal: The Cochrane Database of Systematic Reviews

Article Title: Parenteral versus oral iron therapy for adults and children with chronic kidney disease

doi: 10.1002/14651858.CD007857.pub3

Figure Lengend Snippet: Li 2008 HD

Article Snippet: Random sequence generation (selection bias) , Low risk , Simple block randomisation from block randomisation lists generated with Graphpad Statmate.

Techniques: Infection, Sequencing, Selection

Journal: The Cochrane Database of Systematic Reviews

Article Title: Parenteral versus oral iron therapy for adults and children with chronic kidney disease

doi: 10.1002/14651858.CD007857.pub3

Figure Lengend Snippet: Li 2008 PD

Article Snippet: Random sequence generation (selection bias) , Low risk , Simple block randomisation from block randomisation lists generated with Graphpad Statmate.

Techniques: Infection, Sequencing, Selection

Journal: The Cochrane Database of Systematic Reviews

Article Title: Parenteral versus oral iron therapy for adults and children with chronic kidney disease

doi: 10.1002/14651858.CD007857.pub3

Figure Lengend Snippet: Lye 2000 HD

Article Snippet: Random sequence generation (selection bias) , Low risk , Simple block randomisation from block randomisation lists generated with Graphpad Statmate.

Techniques: Infection, Sequencing, Selection

Journal: The Cochrane Database of Systematic Reviews

Article Title: Parenteral versus oral iron therapy for adults and children with chronic kidney disease

doi: 10.1002/14651858.CD007857.pub3

Figure Lengend Snippet: Macdougall 1996 HD,PD,CKD

Article Snippet: Random sequence generation (selection bias) , Low risk , Simple block randomisation from block randomisation lists generated with Graphpad Statmate.

Techniques: Infection, Sequencing, Selection

Journal: The Cochrane Database of Systematic Reviews

Article Title: Parenteral versus oral iron therapy for adults and children with chronic kidney disease

doi: 10.1002/14651858.CD007857.pub3

Figure Lengend Snippet: Macdougall 1999 HD,PD

Article Snippet: Random sequence generation (selection bias) , Low risk , Simple block randomisation from block randomisation lists generated with Graphpad Statmate.

Techniques: Sequencing, Selection

Journal: The Cochrane Database of Systematic Reviews

Article Title: Parenteral versus oral iron therapy for adults and children with chronic kidney disease

doi: 10.1002/14651858.CD007857.pub3

Figure Lengend Snippet: McMahon 2009 CKD

Article Snippet: Random sequence generation (selection bias) , Low risk , Simple block randomisation from block randomisation lists generated with Graphpad Statmate.

Techniques: Sequencing, Selection, Blocking Assay, Generated

Journal: The Cochrane Database of Systematic Reviews

Article Title: Parenteral versus oral iron therapy for adults and children with chronic kidney disease

doi: 10.1002/14651858.CD007857.pub3

Figure Lengend Snippet: Michael 2007 HD

Article Snippet: Random sequence generation (selection bias) , Low risk , Simple block randomisation from block randomisation lists generated with Graphpad Statmate.

Techniques: Sequencing, Selection

Journal: The Cochrane Database of Systematic Reviews

Article Title: Parenteral versus oral iron therapy for adults and children with chronic kidney disease

doi: 10.1002/14651858.CD007857.pub3

Figure Lengend Snippet: Mudge 2009 TX

Article Snippet: Random sequence generation (selection bias) , Low risk , Simple block randomisation from block randomisation lists generated with Graphpad Statmate.

Techniques: Concentration Assay, Sequencing, Selection

Journal: The Cochrane Database of Systematic Reviews

Article Title: Parenteral versus oral iron therapy for adults and children with chronic kidney disease

doi: 10.1002/14651858.CD007857.pub3

Figure Lengend Snippet: Nagaraju 2013 CKD

Article Snippet: Random sequence generation (selection bias) , Low risk , Simple block randomisation from block randomisation lists generated with Graphpad Statmate.

Techniques: Infection, Sequencing, Selection, Generated

Journal: The Cochrane Database of Systematic Reviews

Article Title: Parenteral versus oral iron therapy for adults and children with chronic kidney disease

doi: 10.1002/14651858.CD007857.pub3

Figure Lengend Snippet: Pisani 2014 CKD

Article Snippet: Random sequence generation (selection bias) , Low risk , Simple block randomisation from block randomisation lists generated with Graphpad Statmate.

Techniques: Clinical Proteomics, Infection, Sequencing, Selection, Generated

Journal: The Cochrane Database of Systematic Reviews

Article Title: Parenteral versus oral iron therapy for adults and children with chronic kidney disease

doi: 10.1002/14651858.CD007857.pub3

Figure Lengend Snippet: Qunibi 2011 CKD

Article Snippet: Random sequence generation (selection bias) , Low risk , Simple block randomisation from block randomisation lists generated with Graphpad Statmate.

Techniques: Infection, Sequencing, Selection

Journal: The Cochrane Database of Systematic Reviews

Article Title: Parenteral versus oral iron therapy for adults and children with chronic kidney disease

doi: 10.1002/14651858.CD007857.pub3

Figure Lengend Snippet: Souza 1997 HD

Article Snippet: Random sequence generation (selection bias) , Low risk , Simple block randomisation from block randomisation lists generated with Graphpad Statmate.

Techniques: Sequencing, Selection

Journal: The Cochrane Database of Systematic Reviews

Article Title: Parenteral versus oral iron therapy for adults and children with chronic kidney disease

doi: 10.1002/14651858.CD007857.pub3

Figure Lengend Snippet: Svara 1996 HD

Article Snippet: Random sequence generation (selection bias) , Low risk , Simple block randomisation from block randomisation lists generated with Graphpad Statmate.

Techniques: Sequencing, Selection

Journal: The Cochrane Database of Systematic Reviews

Article Title: Parenteral versus oral iron therapy for adults and children with chronic kidney disease

doi: 10.1002/14651858.CD007857.pub3

Figure Lengend Snippet: Tsuchida 2010 HD

Article Snippet: Random sequence generation (selection bias) , Low risk , Simple block randomisation from block randomisation lists generated with Graphpad Statmate.

Techniques: Transplantation Assay, Sequencing, Selection

Journal: The Cochrane Database of Systematic Reviews

Article Title: Parenteral versus oral iron therapy for adults and children with chronic kidney disease

doi: 10.1002/14651858.CD007857.pub3

Figure Lengend Snippet: Wang 2003 HD

Article Snippet: Random sequence generation (selection bias) , Low risk , Simple block randomisation from block randomisation lists generated with Graphpad Statmate.

Techniques: Sequencing, Selection

Journal: The Cochrane Database of Systematic Reviews

Article Title: Parenteral versus oral iron therapy for adults and children with chronic kidney disease

doi: 10.1002/14651858.CD007857.pub3

Figure Lengend Snippet: Warady 2002 HD

Article Snippet: Random sequence generation (selection bias) , Low risk , Simple block randomisation from block randomisation lists generated with Graphpad Statmate.

Techniques: Infection, Sequencing, Selection